30 and JAK kinase in COS cells inhibited the association of gp! 30 and JAK kinase. AES contains a glutamine-rich (Q) domain in its N-terminal, which sharing high homology with the amino terminal region of Groucho/TLE(transducin like enhancer of split).

• AES的N-末端约130个氨基酸中富含谷氨酰眩(Q)残基，形成一个Q结构域，与转录协同抑制分子TLE(transducin like enhancer of split)的氨基端高度同源。