A cortical injury in rats was made by the impact method described by Dennis. Animals were sacrificed at 6 hours, 24 hours and 48 hours, respectively after injured. Water content in brain was measured as an indicator of brain edema.

• 分别于伤后6小时、24’J’时、48小时处死动物，应用干湿重法测定大脑含水量，应用组织学方法观察脑组织病理改变与神经细胞超微结构的差别，同时测定大鼠脑皮层组织 Na＋K＋ATP酶、SOD活性和 MDA水平，评价大黄多糖对脑外伤大鼠的脑保护作用。