A medicinal chemistry campaign, in conjunction with a chemical mutagenesis program, was thus launched at Merck &Co. to develop (+)- 1 as a novel anti-flea therapeutic agent for companion animals.

• 一药物化学运动；结合化学诱变节目因此推出与默克公司开发(+)-1作为一种反蚤剂治疗同伴动物.