AIM and METHODS: Matrine (50mg/L) potentiated the cytotoxicity of daunorubicin (DNR) in human leukemia multidrug resistance cell line K562/A02 by MTT assay.

• 方法和结果：经MTT法发现苦参碱50mg/L能增加K562/A02对柔红霉素的敏感性，使柔红霉素半数抑制浓度（IC50）由14?92mg/L降至8?29mg/L，部分逆转了K562/A02对柔红霉素耐药性，逆转倍数为1?80倍。