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- Objective To investigate the role of changes in AMPA receptor GluR2 subunit expression in epileptogenesis. 目的研究在癫痫发病过程中,谷氨酸对AMPA受体Glu R2亚单位表达变化的影响。
- AMPA receptor has the important role in epilepsy about its pathogenesis study and therapy. AMPA受体对于癫痫发病机制的研究和治疗均有重要作用。
- When AMPA receptor is activated,lots of intracellular Ca~(2+)result in neurons injury. 在AMPA受体激活时,大量Ca2+内流导致神经损伤。
- The majority of AMPA receptor is a GluR2-containing heterotetramer in hippocampus. 在海马中大部分AMPA受体是以含GluR2的异四聚体的形式存在。
- The nature AMPA receptor is normally Ca~(2+) impermeable due to the expression of GluR2 subunit. 由于GluR2亚单位的表达天然AMPA受体通道对Ca2+不通透。
- In epileptogenesis,glutamates could down-regulate the expression of AMPA receptor GluR2 subunit through activating the AMPA/KA receptor. 在癫痫等疾病中,谷氨酸能通过激活AMAP/KA受体下调AMPA受体GluR2亚单位的表达,参与发病过程。
- AMPA receptor antagonist-CNQX can promote the neural regeneration and recovery of function, but its activator AMPA can depress the neural regeneration. AMPA受体拮抗剂CNQX能有效促进神经再生及功能的恢复,而其激动剂AMPA则相反。
- This paper aims to determine the protective effect of selective AMPA receptor antagonist GYKI 52466 on HIBD in neonatal rats and investigate its mechanism. 研究选择性AMPA受体拮抗剂GYKI-52466对新生鼠HIBD的保护作用及机制。
- GluR2-lacking AMPA receptors appeared high permeability to Ca 2+. 缺乏GluR2的AMPA受体通道对Ca2 + 有很高的通透性。
- These attach themselves to nerve-cell proteins called AMPA receptors. 这些依附于神经元细胞自己的叫做AMPA接收器。
- Objective: To investigate the effects of Panax notoginseng saponins on expression of excitatory amino acid receptor GluR2 subunit of AMPA receptor in the rat forebrain after intracerebral hemorrhage(ICH). 目的:研究三七总皂甙对脑出血大鼠前脑兴奋性氨基酸受体AMPA受体亚基GluR2表达的作用。
- The response enhancement could also be eliminated by a potentantagonist of Ca2+-permeable AMPA receptor (CP-AMPAR), which suggests the possibility that Ca2+ influx via glutamate-gatedcalcium channels is related to the changes of [Ca2+]i. 另外,反应增强现象还可以被钙离子通透的AMPA受体(Ca2+-permeableAMPAreceptor,CP-AMPAR)的拮抗剂阻断,说明通过钙离子通透的谷氨酸受体内流的Ca2+与胞内Ca2+浓度的改变有关。
- The distribution and match relationship of the 4 subunits of AMPA receptor (AMPAR) and glutamate (Glu) in the caudal trigeminal subnucleus (Vc) of rat were immunohistochemically investigated by using ABC method. 本文用免疫组织化学ABC法调查了4种AMPA受体亚单位(GluR1、2/3、4)和谷氨酸(Glu)在大鼠三叉神经尾侧亚核(Vc)内的分布及其匹配关系。
- Objective To explore the epileptogenesis effect of the AMPA receptors. 目的 为了研究AMPA受体在癫痫发生中的作用。
- Methods After exposure to 5 W/cm~2 microwave, the change of PKC kinase activity in rat hippocampus was detected by Takai method, AMPA receptor phosphorylation level was determined by Western-blotmethod. 方法以峰值功率密度为5W/cm2的微波持续辐照大鼠1,3,5,10,15d,用改良的Takai法检测海马PKC活性,用Western-blot法检测海马AMPA受体磷酸化程度。
- Methods Using RT-PCR and Western Blot methods,the changes of AMPA receptor GluR2 subunit mRNA and protein expressions were observed in cultured hippocampal neurons of rats induced by glutamate. 方法用RT-PCR和Western Blot方法观察谷氨酸诱导培养大鼠海马神经元AMPA受体Glu R2亚单位mRNA和蛋白的表达变化。
- The glutamate receptor interacting protein 1 (GRIP1) is a scaffolding protein in postsynaptic density (PSD), tethering AMPA receptors to other signaling proteins. GRIP1可以直接与AMPA受体相互作用并将之与其它信号蛋白联结在一起。
- AMPA receptors mediate the fast excitatory synaptic transmission in the central nervous system. AMPA受体介导了中枢神经系统绝大部分快速型的兴奋性突触传递。
- At these synapses, most of baseline synaptic transmission is mediated by glutamate AMPA receptors. 在正常条件下, 大多数的突触反应是由谷氨酸的AMPA受体传递的。
- The above results suggest that the expression change of AMPA receptors GluR2 subunit may play an important role during seizures. 在癫痫发作过程中AMPA受体 GluR2亚单位表达改变可能与癫痫发作导致的神经元损伤有密切关系。