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APC gene mutation is a critical genetic event in both the familial and sporadic forms of colorectal tumorigenesis. 结肠腺瘤性息肉基因的突变是家族型和散发型结肠癌的发生中危险的基因事件。
Mutation of APC gene occurs not only in FAP, but also in sporadic colorectal tumors. APC不仅在FAP中存在突变，而且在散发性大肠肿瘤中亦存在突变；
The APC gene was identified in 1991 at chromosome 5 q 21. which is responsible for the familial adenomatous polyposis (FAP). APC基因是1991年被发现的一类肿瘤抑制基因,它被定位于人第5号染色体5q21处。
In colorectal carcinoma, APC gene mutation was not related to size, location, histologic features and lymph node metastases. 实验结果表明，APC基因在散发性大肠腺瘤与大肠癌中均有较高突变频率，两者差异无显著性；
Benedetti LD, Sciallero S, Gismoodi V, et al. Association of APC gene mutations and histological characteristic of colorectal adenomas. Cancer Res1994;54:3553-3556. 潘林娜，张志燕，赵洪清.;结直肠息肉与结直肠癌的演变特性分析
To the catastrophe of the APC gene possess very important significance, it can conduce to the research of tumorous aetiology, nosogenesis and early diagnosis. 检测APC基因突变具有重要的意义，有助于对肿瘤病因学、发病机制及早期诊断的研究。
In vitro synthesized protein assay(IVSP), which selectively detected any mutation generating stop codon, was used for rapid detection of APC gene mutation in 115 cases of non FAP colorectal tumors. 为了快速检出APC基因突变，应用选择性检测产生终止密码突变的体外蛋白合成试验（IVSP），对115例Non－FAP大肠肿瘤标本进行了研究。
Mutation of APC gene in sporadic colorectal tumors 大肠肿瘤APC基因突变的研究
In SW1116 and Colo 320 cells, the expression of p16 INK4A and APC genes was markedly increased after treatment of 5 aza dC, although 5 aza dC treatment did not activate the expression of p21 WAF1 gene. 以 5 aza dC干预后 ,p1 6 INK4A和APC表达增强 ,且不同的结肠癌细胞系表达增强最明显时 5 aza dC干预的时间与浓度不同。
The expression of c-myc was not significant different in SW116 and Colo-320 cells treated by 5-aza-dC. Conclusion The expression of p16 INK4A and APC genes was regulated by DNA methylation in three human colon cancer cells. 结论三株人结肠癌细胞中 ,5 aza dC均可诱导 p16 INK4A和APC的表达 ,但对 p2 1WAF1和c myc无明显影响。
RESEARCH ON APC GENE MUTATION OF TUMOR TISSUES AND STOOLS 大肠癌病人粪便和组织中APC基因突变的研究
Expression of APC gene protein in non-small cell lung cancer APC蛋白在非小细胞肺癌组织中的表达
Characteristics of APC gene mutations in colorectal tumors 大肠肿瘤结肠腺瘤病基因突变的特征
DETECTION OF APC GENE MUTATIONS IN 41 CASES OF COLORECTAL CANCER 41例大肠癌组织APC基因突变检测
Detection of APC Gene Mutation in Pancreatic Carcinoma by PCR SSCP PCR-SSCP法检测胰腺癌APC基因突变
Mutations of APC Gene in MCR in Human Colorectal Carcinoma PCR-SSCP法检测大肠癌APC基因MCR区段基因突变
Keywords adenomatous polyposis coli;APC gene;mutation; 腺瘤息肉病;结肠;APC基因;突变;
USING IVSP ASSAY FOR RAPID DETECTION OF APC GENE MUTATION IN COLORPECTAL TUMOR 应用 IVSP 法快速检测大肠肿瘤 APC 基因突变
Expression of APC gene protein in colorectal mucosa, adenoma and adenocarcinoma APC蛋白在大肠粘膜、腺瘤及大肠腺癌中的表达
Please wait a minute,I'll get some APC for you. 请等一会，我给您拿几片APC。