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- The concordance between loss of expression and aberrant methylation of RASGRF2 was 86% (12/14) in cell lines. RASGRF2 在肺癌细胞表达降低和异常甲基化的吻合率为86%25 (12/14);
- Aberrant methylation of DNA has been recognized as common epigenetic changes in human cancer. DNA异常甲基化是肿瘤常见的表观遗传学改变。
- And the detection of Dnmt-1 protein expression and P16/MGMT aberrant methylation is helpful for the diagnosis of uterine cervical cancers. 结论Dnmt-1蛋白表达和P16/MGMT基因启动子甲基化在宫颈癌进展过程中的早期就起着非常重要的作用,而且Dnmt-1蛋白表达和P16/MGMT甲基化检测对于恶性肿瘤的诊断有着重要的辅助意义。
- Objective:To investigate the role of aberrant methylation of p16 and CDH 1 in cervical carcinoma and evaluate their clinical significance. 目的:分析宫颈癌和宫颈上皮内瘤样病变(cervical intraepithelial neoplasia, CIN)组织中p16和CDH1基因异常甲基化的变化,评价该指标在宫颈癌中的意义。
- Aberrant methylation of DNA is frequently found in tumor cells and tumor suppressor genes hypermethylation may also play an important role in carcinogenesis. 肿瘤可发生许多基因的异常甲基化,尤其是抑癌基因的高甲基化对肿瘤发生有很重要的作用。
- Decreased RASGRF2 expression was presented in 36% (5/14) lung cancer cell lines while aberrant methylation of RASGRF2 was present in 29% (4/14) lung cancer cell lines. RASGRF2 在 36%25 (5/14)的肺癌细胞中表达降低,而在 29%25 (4/14) 肺癌细胞中存在异常甲基化。
- The aberrant methylation in some genes is strongly associated with colorectal cancer,and this methylation occurs during the early stage of colorectal cancer. 某些基因异常甲基化与结肠癌发生密切相关,且常见于结肠癌发病早期。
- Methods: Methylation-specific PCR(MSP) was used to detect the frequency of aberrant methylation of RASSF1A and p16 gene in 96 human NSCLC tissues and matched 96 normal lung tissues far from cancer area. 方法:用甲基化特异性PCR(MSP)方法对96例NSCLC患者癌组织及相应的远癌正常肺组织中RASSF1A和p16基因启动子甲基化状态进行检测。
- Objective: To analyze the aberrant methylation of death-asscciated protein kinase (DAPK) gene in blood from non-small cell lung cancer (NSCLC) patients and to evaluate its clinical significance. 目的:分析非小细胞肺癌(NSCLC)患者血清中死亡相关蛋白激酶(DAPK)基因启动子区域甲基化的改变状况及其临床意义。
- During mammalian embryonic development, DNA methylation is an essential process in the regulation of transcription.There are many aberrant methylation in various genomic regions of cloned embryos. 哺乳动物种系中,DNA甲基化是胚胎发育期转录调节的必需步骤,除了单拷贝基因序列外,在基因组很多的区域都可以观测到克隆胚胎的异常甲基化。
- Aberrant methylation of CpG islands in thrombospondin 1 gene and its clinical significance in gastric adenocarcinoma 胃腺癌凝血栓蛋白1基因异常甲基化及其临床意义
- Fragile histidine triad gene aberrant methylation and its expression in gastric carcinoma 胃癌中脆性组氨酸三联体基因的甲基化和表达及其意义
- Study on the aberrant methylation and protein of p16 gene in patients with colorectal cancer 结直肠癌中p16基因的甲基化改变与蛋白表达的关系
- Clinicopathological significance of aberrant methylation of the fragile histidine triad gene in patients with hepatocellular carcinoma 肝细胞癌中脆性组氨酸三联体基因的甲基化状况及其临床意义
- Objective: To detect the aberrant methylation of Ras association domain family 1A (RASSF1A) in the tissue and the serum from ovarian tumor patients; 目的:检测卵巢肿瘤组织和血清中Ras相关区域家族1A(Ras association domain family 1A,RASSF1A)基因的异常甲基化;
- Aberrant methylation 异常甲基化
- Tending to deviate, as from a normal or recognized type; aberrant. 变异的倾向于偏离,如从一个正常的或被承认了的类型; 畸变的
- Rhetoric is abyssal and aberrant. 修辞是深奥而异常的。
- Allene is an isomer of methyl acetylene. 丙二烯是甲基乙炔的一种异构体。
- Methylation of chromatin causes it to condense. 染色质甲基化后会出现凝缩。