Abnormal change of ArE/PON1and dyslipidosis in patients with DN_CRF was more se-rious than that in CHN_CFR. Serum ArE/PON1was one of the good indexes to early inflect the disorder of lipid metabolism of CRF especially for DN_CRF.

• DN_CFR组ArE/PON1和脂代谢紊乱严重于CHN_CFR ,ArE/PON1活性测定是一种能反映CFR脂代谢紊乱和肾功能损害的指标。