Abstract:Objective To investigate the mechanism of methotrexate (MTX) on human keratinocyte in vitro,and to understand the therapeutical mechanism of MTX on psoriasis.

• [摘要]目的 探讨甲氨蝶呤（MTX）对表皮角质形成细胞的作用及影响，进而了解MTX治疗银屑病的机理。