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- The drug-resistance mechaniam of shigella caused by producing inactived enzyme,changing cell walls,target site structure and active efflux pump. 志贺菌的耐药机制主要是产生灭活酶、细胞壁的改变、主动外排以及作用靶位结构的改变。
- Objective To study the mechanism of multiple-antibiotic-resistance in clinical isolates of Shigella and to detect the distribution and expression of active efflux pump gene acrAB-tolC. 目的研究志贺菌患者分离株的多重耐药机制。 方法检测志贺菌中有无主动外排系统acrAB-tolC结构基因acrAB-tolC在临床分离菌株中的分布;
- To investigate multiple-antibiotic-resistance mechanism in Escherichia coli, the distribution of active efflux pump gene, acrAB, were determined by PCR, Southern bolt, and its expressions by RT-PCR, in clinical strains of Escherichia coli. 为了研究临床分离多重耐药大肠杆菌的耐药机制,我们采用PCR和Southernblot检测大肠杆菌主动外排系统AcrAB结构基因acrAB在临床分离菌株中的分布并用RT-PCR测定其mRNA表达水平。
- To study the mechanism of multidrug resistance in c1inical isolates of Klebsiella pneumoniae and detect the dis-tribution and expression of active efflux pump gene acrAB, homologous to that in Escherichia coli. 目的:研究临床分离多重耐药肺炎克雷伯菌的耐药机制,检测肺炎克雷伯菌中有无类似大肠埃希菌主动外排系统AcrAB的结构基因acrAB的分布和表达。
- Distribution and expression of active efflux pump acrAB in clinical isolates of Klebsiella pneumoniae 主动外排系统acrAB在临床分离肺炎克雷伯菌中的分布和表达
- THE DISTRIBUTION AND EXPRESSION OF ACTIVE EFFLUX PUMP acrAB IN CLINICAL ISOLATES OF ESCHERICHIA COLI 主动外排系统acrAB在临床分离大肠杆菌中的分布和表达
- Distribution and expression of active efflux pump acrAB in clinical isolates of Shigella 主动外排系统acrAB在志贺菌中分布和表达
- Active efflux pump 主动外排
- Objective: To investigate active efflux of drugs in clinical isolated strains of Escherichia coli. 目的:研究临床分离的大肠杆菌多重耐药株和敏感株中抗菌药物的主动外排系统。
- Objective:To explore the role of efflux pump in drug resistance to fluoroquinolones in Stenotrophomonas maltophilia. 目的:探讨主动外排泵在嗜麦芽寡养单胞菌对氟喹诺酮类药物耐药中的作用。
- Objective To investigate the active efflux of fluoroquinolones in clinical isolated strains of Escherichia coli. 目的研究临床分离的大肠杆菌敏感株和多重耐药菌株体内的氟喹诺酮类药物积聚情况与耐药性的关系。
- ABSTRACT Objective To investigate the role of efflux pump of Acinetobacter baumannii mutant strains against fluoroquinolones. 目的探讨主动外排泵在鲍曼不动杆菌诱导突变株对氟喹诺酮类药物敏感性的影响。
- ESBLs,AmpC,VIM,IMP,OXA23,OXA-24 and outermembrane protein were detected. Reserpine synergistic inhibition test was used to study the active efflux mechanism. 检测ESBLs、AmpC酶、VIM、IMP、OXA-23和OXA-24产生及外膜蛋白表达情况,利血平协同抑制试验检测膜外排机制。
- P-glycoprotein is an ATP-driven efflux pump which transport a wide variety of structurally diverse compounds from the cell interior into the extracellular space. 糖蛋白是一个能量依赖性转运蛋白,能将许多结构不同的化合物逆向转运出细胞。
- Intestinal CYP3A4-mediated biotransformation and active efflux of absorbed drug by P-glycoprotein are major determinants of bioavailability of orally administered drugs. 肠CYP3A4介导的生物转化和P糖蛋白介导的药物主动泵出肠细胞是决定口服药物生物利用度的主要因素。
- Conclusion: There was active efflux of tetracycline and penicillin in clinical isolated strains of Escherichia coli, but the capability was less than in Mar strains. 结论:临床分离的敏感株中亦存在能泵出四环素和青霉素的主动外排系统,但其外排功能显著低于多重耐药株。
- The acrAB locus encode the efflux pump AcrAB,which confers multidrug tolerance,controlled by the regulon marRAB. Mutation in the gyrase and topoisomerase IV lead to fluoroquinolones resistance, mainly arise in gyrA and parC genes. AcrAB外流泵系统的合成有多重耐药调节子 (marRAB)调控 ,AcrAB与多种抗生素的耐药有关。 拓扑异构酶 (topoisomerase)的突变主要与氟喹诺酮类药物的耐药性有关 ,突变主要发生在gyrA ,parC基因上
- It suggested that the level of resistance of isolates would be related to selecting pressure of fluoroquinolones and induced gene mutations of DNase and topoisomerase IV could not activate AcrAB efflux pump system. 提示临床分离的鸡大肠杆菌O 78的耐药水平与喹诺酮类药物的选择性压力有关,它诱导了DNA旋转酶和拓扑异构酶IV的基因突变,可能不能激活A crAB外输泵。
- The investigation suggests that Mar phenotype of Escherichia coli be determined by the levels of active efflux system acrAB gene expression, and the expression of acrAB gene should be regulated by mar operon. 本研究表明大肠杆菌acrAB表达水平决定了大肠杆菌多重耐药表型,mar可能调控acrAB的表达。
- The mechanism of bacterial efflux pumps is one of the important factors resulting in bacterial multidrug resistance. 细菌耐药性,尤其是多重耐药问题日益严重,给临床治疗带来极大的困难。