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- Activation of telomerase may be a good biomarker for preneoplastic lesions, and associates with cell malignancy. 端粒酶的激活可能是癌前病变的一种生物学标记物,与细胞恶性变的发展有密切关系。
- Therefore, to control the activity of telomerase effectively may give a new way for people to surmount c... 因此,有效地控制端粒酶活性,有可能为人类攻克癌症提供一个新的契机。
- Results:These two drugs could inhibit the proliferation of QGY cells,block the cell cycle,induce its apoptosis and inhibit the activity of telomerase. 结果:两种药物均具有抗QGY细胞增殖、阻滞细胞周期、诱导凋亡及抑制端粒酶活性的作用。
- Results:Oridonin could decrease the activity of telomerase, as well as cause apoptosis and inhibit the growth of K562 cells significantly. 并呈现出明显的量-效与时-效关系。
- Activation of telomerase and prolonging of RTF length might be involved in t he process of ginsenoside Rg1 protection against t-BHP-induced senescence in W I-38 cells. 人参皂苷Rg1可能通过激活端粒酶活性和减少端粒长度缩短而发挥其抗t BHP诱导的WI 38细胞衰老作用。
- Results The activity of telomerase were 76.2% in gastric carcinoma (GC) group, 48.6% in astrophic gastritis (AG) group, 15.8% in benign gastric ulcers (BGU) group, respectively. 结果胃癌、萎缩性胃炎、良性胃溃疡中端粒酶活性的分别为76.;2%25,48
- Conclusion:To test the activity of telomerase has certain value in diagnosis of tumor and the activity of telomerase has become one of the important markers of the tumor. 结论:端粒酶活性检测在恶性肿瘤早期诊断,良、恶性鉴别,肿瘤术后复发和预后及治疗等多方面有重要价值,是最重要的临床肿瘤标记物之一。
- Results: These two drugs could inhibit the proliferation of QGY cells, block the cell cycle, induce its apoptosis and inhibit the activity of telomerase. 结果:两种药物均具有抗QGY细胞增殖、阻滞细胞周期、诱导凋亡及抑制端粒酶活性的作用。
- It was found that telomerase activity could be detected in most tumor tissue, which suggested that activation of telomerase may play an important role in tumorigenesis. 研究发现,大多数肿瘤组织细胞中可检测到端粒酶活性,其被认为在肿瘤发生中起重要作用。
- Results The effect of radiation +AZT on the treatment of mouse lymphoma was the best in all groups and it was also the best in decreasing the activity of telomerase. 结果动物实验表明,放疗加AZT对小鼠淋巴瘤的治疗作用优于单纯放疗或者单纯AZT治疗。
- The formation of neurofibromas in the patients with non-NF1 was only associated with the increased activity of telomerase resulting from the increased expression of hTERT protein, and was not associated with the absent expression of NF1 protein. 而非NF1患者神经纤维瘤的形成与hTERT蛋白表达增加,端粒酶活性增高有关,与NF1蛋白表达缺失无关。
- The inhibitory rate of telomerase activity of the cells were determined by P CR-ELISA methods after the cells were treated with 1/4 IC_(50 )EGCG and adri amycin after 24?h, 48?h and 72?h. 将1/4IC50的EGCG和阿霉素作用于肿瘤细胞株24h、48h和72h后,用PCR-ELISA法测定肿瘤细胞的端粒酶活性。
- The activation of telomerase, the ribonucleoprotein responsible for maintaining the ends of chromosomes, has been implicated as the critical step in cellular immortalization and tumorigenesis. 端粒酶通过催化端粒合成,保持端粒长度,从而保证细胞的持续分裂能力,其活性与细胞永生化、肿瘤发生等过程密切相关。
- G-quadruplex plays a very important role in inhibiting the activity of telomerase that has close relation with cellular malignant transformation and maintaining cellular division and proliferation. 端粒酶与肿瘤细胞恶性转化、分裂、增殖密切相关,而稳定G-四链体可以有效抑制端粒酶的活性。
- They embarked on a active of let poeple vote. 他们展开一场动员人们投票的运动。
- The disease shuts the boy off from most of the activities of normal children. 疾病使这个男孩不能参加正常孩子的大部分活动。
- He directs the activities of the club. 他管理俱乐部的活动。
- The mechanism of telomerase activation is still not clear till now. 端粒酶的激活及其调控机制至今仍不清楚。
- He partook in the activities of the school. 他参加了学校的活动。
- Telomerase system is the genetic name of telomerase and telomere. 端粒酶系统是端粒和端粒酶的总称。