Acupuncture to fat rat could make the level of Leptin and Ins decreased in serum but increased in hypothalamus, correct the resistance of Leptin and Ins.

• 明显降低肥胖大鼠血清Leptin和Ins水平，却显著升高肥胖大鼠下丘脑Leptin和Ins水平，有效改善肥胖大鼠的?素抵抗（LR）和胰岛素抵抗（IR）；