Advanced neoplasia, defined as a tubular adenoma 1 cm or greater in diameter, a polyp with a villous histologic appearance, a polyp with high-grade dysplasia, or cancer, occurred in 418 subjects.

• 末期肿瘤的定义，为管状线瘤，直径超过1公分，组织学上出现高度不规则的绒毛状瘜肉或癌细胞，而符合此项定义的患者有418人；