Although the global tolerability of tamoxifen was fine, it will result in gynecological and thromboembolic complications related to its partial agonist effects during long-term treatment.

• 绝经后妇女雌二醇的主要来源为：雄烯二酮在外周组织中的芳香化酶复合物的作用下转化为雌酮，雌酮随后转化为雌二醇。