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- Endogenous angiogenesis inhibitors act as tumor suppressor proteins. 内源性血管生成抑制剂可作为一种抑癌蛋白。
- Two angiogenesis inhibitors have been developed that have a broad spectrum of anticancer activity, yet virtually no side effects. 目前,已有两种具有广谱抗肿瘤活性且无明显副作用的血管生成抑制剂面世。
- Results: Angiogenesis inhibitors have brighter prospects on treatment of lung cancers. 结果:血管生成抑制剂治疗肺癌方法可行,前景诱人。
- Several types of angiogenesis inhibitors reveal a biphasic, U-shaped curve of efficacy. 一些类型的血管生成抑制剂表现出一种双向性,成U行曲线的效能。
- Recently, many endogenous angiogenesis inhibitors have been discovered, some of them are currently in various stages of clinical trials. 近年来,研究发现了多种内源性血管生成抑制因子,其中一些已进入了临床试验阶段。
- This review focused on the structure, function, and mechanism of endogenous angiogenesis inhibitors, and their potential in treating tumor. 本文对内源性血管生成抑制因子的结构、功能、作用机制及其在肿瘤治疗中的应用进行综述。
- Studies on the structure and catalytic mechanism of huMetAP 2 provide the basis for design and synthesis of new angiogenesis inhibitors. 根据甲硫氨酰氨肽酶2的结构以及催化和抑制机制,可以设计和合成新型的血管生成抑制剂;
- Human tests of efficacy are under way and will be a much better judge of whether angiogenesis inhibitors can live up to their very great promise. 至于针对药物效用的人体试验则正进行中,其结果将对这些血管新生抑制剂有更适宜的评价,看看它们是否能不负众望。
- Angiogenesis inhibitor TNP-470 has strong inhibitory effect on tumor growth of human gastric cancer in nude mice. 2. 结论:TNP-470对胃癌生长有抑制作用;
- As the features of angiogenesis inhibitors are of low toxicity and have less acquired resistance,it comes to a new strategy to suppress tumor growth by restraining angiogenesis. 由于抗血管生成药物具有毒性低、不易产生获得性耐药的特点。因此,通过抑制血管生成来抑制肿瘤生长成为目前肿瘤治疗的策略之一。
- Purpose To synthesize a new antitumor drug 2-methoxyestradiol which is an angiogenesis inhibitor. 目的合成抗肿瘤新药新生血管形成抑制剂2甲氧基雌二醇。
- Tumor angiogenesis results from multiple factors,and the imbalance of angiogenic cytokines and angiogenesis inhibitors determine to facilitate or inhibit angiogenesis. 肿瘤血管生成是诸多因素共同作用的结果,其中血管生长刺激因子和血管生长抑制因子作用平衡与否,决定了血管生成是促进还是抑制。
- Objective: To study the effect of the angiogenesis inhibitor SU6668 combined with 5-Fu on liver metastasis in human colon cancer. 目的:探讨血管生成抑制剂SU6668联合5-Fu对人结肠癌肝转移的抑制作用。
- Conclusions The model for tumor neovascularization has been proved to be reliable for the study of the angiogenesis inhibitor. 结论小鼠肿瘤新生血管模型是一种稳定可靠的新生血管模型。
- The distilling technology and bioactivity of angiogenesis inhibitor components from Dasyatis akajei cartilage were studied primarily. 以赤魟软骨为原料,对赤魟软骨中新生血管抑制组分的提取方法及其生物学活性进行了初步研究。
- Conclusion The model for tumor neovascularization has been proved to be reliable for the study of the angiogenesis inhibitor. 结论 小鼠肿瘤新生血管模型是一种稳定可靠的新生血管模型。
- Tumor angiogenesis inhibitor is a class of new drugs that can destroy or inhibit tumor neovascularization,and can effectively block the growth and metastasis of cancer. 肿瘤血管生成抑制剂是一类能破坏或抑制血管生成,有效地阻止肿瘤生长和转移的药物。
- Liu BY, Lin YZ, Yin HR, et al.Experimental study of the effect of angiogenesis inhibitor TNP-470 on the growth and metastasis of gastric[J].Chin J Oncol, 1998, 20(1): 34-6. [6]刘炳亚;林言箴;尹浩然;等.;血管生成抑制剂TNP-470对胃癌生长及转移抑制作用的实验研究[J]
- Based on such tests, doctors will be able to devise treatment plans that, along with other therapies, incorporate a mix of angiogenesis inhibitors appropriate for that individual's tumor. 根据那样的检验,医生将可以设计治疗方案:搭配其他的疗法,用上一组针对该病人的肿瘤所设计的血管新生抑制剂。
- Both upregulation of angiogenic stimulators and downregulation of angiogenesis inhibitors result in tumor blood vessel proliferation, which is the bases of the tumor growth and metastasis. 征募宿主细胞,如巨噬细胞、淋巴细胞、纤维细胞,使它们分泌促血管生长因子。各类促血管生长因子过量表达和血管生成抑制因子下调是导致肿瘤血管增生,引起肿瘤生长和转移的基础。