Angiotensin n receptor subtype 1 (ATI) antagonist valsartan not only decreased SBP and MESS but inhibited the activation of Stat3 and even protein expression of c-myc and occurrence of LVH;

• 结论：肾血管性高血压大鼠左室肥厚过程中，Stat3的活化增加，Stat3可能是参与左室肥厚发生发展的一个新的信号转导及转录说活因子；