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Tumor antigen specific CTLs may prevent metastasis in the LCI-D20 model and prolong the survival time. 肿瘤抗原特异性CTL可以预防LCI-D20模型肝癌发生转移,延长动物存活时间。
In ABM, the remarkably increased expression of co stimulatory molecule CD86 in CD3 - MNC may enhance the anti tumor effect of antigen specific CTLs. ABM中CD3-细胞表面共刺激分子CD86表达明显增加 ,与ABM中特异性细胞毒性T淋巴细胞(CTLs)的生成有关。
The mature DCs were co-cultured with autologous T cells to obtain antigen specific CTL (Ag-CTL) and antigen non-specific CTL (non Ag-CTL). The phenotypes of Ag-CTL were analyzed by flow cytometry. 成熟DCs与自体T细胞共育,分别获得Ag-CTL及non-Ag-CTL,流式细胞仪检测Ag-CTL细胞表型的变化;
Dendritic cells (DCs) are the most potent antigen presenting cells (APCs) that prime naive T lymphocytes and active antigen specific cytotoxic T lymphocytes(CTLs), which makes DC a promising tools for immunotherapy of cancer . 树突状细胞(Dendritic Cells,DCs)作为功能最强的抗原提呈细胞，在恶性肿瘤的免疫治疗中起着重要的作用。
The tumor specific CTL was generated form activated autologous T cell by DC vaccine loaded with tumor antigen, and the killing activity of CTL to CT26 cells was tested by the lactate dehydrogenase (LDH) release assay in vitro. 负载肿瘤抗原的DC疫苗激活同源T淋巴细胞产生细胞毒性T淋巴细胞(CTL),采用乳酸脱氢酶(LDH)4h释放法检测CTL在体外对CT26细胞的杀伤活性;
Flow cytometry analysis indicated that the tetramer could bind to specific CTL from HLA-A11+ donor. 流式细胞仪分析显示所制备的四聚体可与HLA-A11+供者的抗原特异性CTL结合。
The therapeutic vaccine could induce strong specific CTL activity in HLA-A2 transgenic mice. 其在HLA-A2转基因鼠中可诱导出强的表位特异性细胞毒性T淋巴细胞活性。
Autoantibodies of AIHA have blood type antigen specificity. 自身免疫性溶血性贫血(AIHA)的自身抗体具有血型抗原特异性。
For either HIV-1B or HIV-1C, Gag and Nef were preferentially targeted by HIV-1 specific CTLs, Rev and Tat proteins were also recognized to different extent. 无论HIV- 1B亚型还是HIV- 1C亚型所构建肽库的应答强度和频率, 主要集中在Gag和Nef蛋白, Tat和Rev蛋白也有不同程度的应答。
Methods we detected the changes of antigen specific AFC and sIgA in in- testinal mucosa by ELISPOT and ELISA assay. 方法采用 ELISPOT 和 ELISA 法检测了胃粘膜、PP 结抗原特异性形成细胞(AFC)和小肠粘液 sIgA。
The specific CTL cell mediated immune responses induced by live attenuated and inactivated Japanese encephalitis(JE) vaccine in mice were compared. 应用检测特异性CTL活性的方法检测乙脑活疫苗的细胞免疫应答 ,并以灭活疫苗作对照。
MethodsThe changes of antigen specific AFC in gastric and intestinal mucosa were detected by ELISPOT assay. 方法采用 EL ISPOT法检测了胃粘膜、肠粘膜相关淋巴组织 PP结抗原特异性形成细胞 (AFC)。
An antigen specific test showed that the recombinant did not have any cross-reaction with chicken H5 and H9 anti-sera. 抗原特异性试验证明,重组HA1蛋白与鸡H5、H9亚型AIV抗血清不发生交叉反应。
CT26 colorectal adenocarcinoma-bearing mice model were established and treated with the tumor specific CTL, the tumor size and the survival period of mice were monitored. 建立CT26荷瘤小鼠模型,应用CTL治疗荷瘤小鼠,观察肿瘤大小和小鼠存活期。
Antigen specific immune tolerance is induced in a mammalian host by administration of a toleragen in combination with a regimen of immunosuppression. 通过施用耐受原与免疫抑制方案相组合诱导哺乳动物宿主中的抗原特异性免疫耐受。
BCG-CpG-DNA increased the anti-HBs neutralizing antibody level,promoted the production of antigen specific IgG2a,induced Th1 immune response,and partially reversed Th2 response. BCG-CpG-DNA能提高抗-HBs中和抗体水平,促进抗原特异性IgG2a的产生,诱导Th1型免疫应答,与铝佐剂协同作用能部分逆转Th2反应。
The results demonstrated that there was competitive inhibition between peptides (E7_7-15, E7_66-74, E7_82-90) and epitopes (E7_11-19, E7_49-57), and specific CTLs induction was influenced by the peptides distinctively. 第二位氨基酸残基都定位于HLA-A2.;1分子肽结合槽的B凹槽附近；第二位氨基酸残基的Ca和羧基末端氨基酸残基的Ca之间距离分别为P3 （E7_ 49-57）17
The aim of our study is to investigate the expression of HSP70 and HSP70 antibody in serum of patients infected with HCV and the role of HSP-peptide complex in induction of specific CTLs in vitro. 因此，我们研究HSP70、HSP70抗体在HCV感染者血清中的表达及HSP70-肽复合物对HCV特异性CTL的作用，可为研制新型的丙肝CTL疫苗积累资料，为丙肝的防治提供一种可能有效的手段。
Internationa Diabetes: On the issue of antigen specific prevention therapy for type I diabetes， which in your opinion is more involved， the auto-antibody or auto-reactive cells? 国际糖尿病：您提到1型糖尿病抗原特异性的预防措施，您认为是自身免疫抗体重要还是自身免疫细胞重要？
Suppression of allo-specific CTL activity in allo-TCV immunized mice; the activity of specific CTL to alloantigen generated by in vitro bulk MLR in TCV group was much lower than that in. 在CML实验里,同种抗原特异TCV免疫小鼠的脾细胞体外诱导同种CTL活性明显受到抑制,CTL 活性十分低下。