As blockage of CMA increases cellular vulnerability to stressors, we propose that dopamine-induced autophagic inhibition could explain the selective degeneration of PD dopaminergic neurons.

• 由于CMA的阻断增加了细胞对应激原的易损性,我们认为多巴胺诱导的自噬抑制可以解释PD多巴胺能神经元的选择性变性。