Background The abrogation of function of the tumor-suppressor protein p53 as a result of mutation of its gene, TP53, is one of the most common genetic alterations in cancer cells.

• 背景肿瘤抑制蛋白p53由于其基因TP53突变而造成功能缺失，是肿瘤细胞最常见的基因变异。