By guided-selection and chain shuffling technique, the humanized Fab antibody against HAb18G is obtained, which lays the foundation for further research.

• 利用导向选择链更替技术 ,筛选出特异性较强、完全人源化的抗肝癌抗原HAb18G的Fab抗体 ,为进一步的工作打下了基础。