Cefquinome sulfate was prepared from cefotaxime via 3-substitution,salt formation,and salt exchange with sulfuric acid by anion exchange resin.

• 以头孢噻肟酸为原料；经3位取代、成盐、离子交换、硫酸成盐；最终得到标题化合物；总收率35.；9%25。