Cell degeneration was gradually aggravated and cell necrosis and karyopycnosis occurred in some organs sach as heart, liver, brain and spllen in crest-time.

• 高峰期表现为细胞变性加剧，部分器官如心脏、肝脏、脑、脾脏出现细胞坏死、核固缩为特征的病理变化；