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- Chromosome aberrations were incuced with both arsenic compounds. 两种砷酸盐均可引起染色体畸变。
- These chromosome aberrations are all stable, compatible with cell viability. 这些染色体畸变都是稳定的,不影响细胞生活力的。
- Trisomy 7 and trisomy 12 are common chromosome aberrations in lymphoma. +7和+12是淋巴瘤常见的染色体畸变。
- Additionally, several types of chromosome aberrations were observed in somatic cells of the normal alpacas . 此外,本研究还观察到正常羊驼染色体畸变类型,包括数目畸变和结构畸变,数目畸变如三倍体、四倍体;
- Methods: The chromosome aberrations and the rate of micronuclei in peripheral lymphocytes were examined. 方法:外周血淋巴细胞染色体畸变分析采用微量全血培养法,微核测定采用甲基纤维素法。
- Among those with chromosome aberrations 71 (16. 4%) showed recurrent miscarriage or stillbirth. 染色体异常和异态患者中患有反复自发流产、死胎等不良妊娠者为16.;4%25(71/432);
- The results indicated that the yields of chromosome aberrations induced by EA and EAA were markedly higher than the treatment with EMS. 实验结果表明;它们的诱发染色体畸变率均高于EMS诱发的畸变率;即分别提高为11.;2%25和7
- Chromogenic In situ hybridization is used to detect specific nucleic acid sequences in tissue cell or chromosome aberrations. 显色原位杂交法可用于对组织/细胞或染色体畸变中的特异核酸序列进行检测。
- Objective:To investigate the roles of the chromosome aberrations and fragile sites in the nasopharyngeal cancer (NPC) family. 目的:探讨染色体畸变和脆性部位表达在鼻咽癌家族发病中的意义。
- Conclusion The study showed that FISH was more sensitive than traditional cytogenetics in detection of chromosome aberrations. 结论本实验结果表明FISH在检测染色体畸变中比细胞遗传学核型分析方法敏感。
- Purpose and Methods: Single cell gel electrophoresis(SCGE), sister chromatid exchanges(SCE), chromosome aberrations are three methods to determine DNA damage and repair. 目的与方法 :单细胞凝胶电泳技术 (SCGE)、姐妹染色单体交换法 (SCE)和染色体畸变分析法均能被用来检测DNA的损伤或修复。
- Methods Backward mutation was detected by the Ames test. The chromosome aberrations (CA) was detected by the CHL cells test and the micronuclei test (MN). 方法 用Ames实验检测回复突变作用,以CHL细胞实验和微核实验检测染色体畸变效应。
- All of 17 cases detected by CGH showed chromosomal aberrations. CGH技术检测的17例肺癌标本中均检出染色体畸变(扩增和/或缺失),而且每个病例涉及多条染色体畸变。
- The capabilities of three components of PYM, A2, A5 and A6 for inducing chromosome aberrations and SCEs were studied. The results indicated that all three components of PYM could induce aberrations. 本文报道平阳霉素(Pingyangmycin,PYM)的三种成分A_2、A_5和A_6诱发CHO-K1细胞染色体畸变和姐妹染色单体交换(SCEs)。
- The total cumulative dose for each groupwas 2.0 Gy. It was found that the types of chromosome aberrations were mainly dicentric abe-rrations and acentric fragments in single acute irradiation. 慢性连续照射以0.;26 mGy/min的剂量率;每天照射190分钟;每周连续照射5天;总累积剂量均为2
- Methods: The clinical, hematology and chromosome aberrations of bone marrow cells on 19 cases of psoriasis with leukemia and chromosome aberrations of lymphocytes of peripheral blood on 14 cases with untreated psoriasis were studied. 方法:对19例银屑病合并白血病患者的临床表现、血液学、骨髓染色体和14例初治的银屑病患者的外周血淋巴细胞染色体进行研究。
- The relations were analyzed among clinical symptom, accumulated dose, endoscopic findings of esophagus, pathological changes and the rate of chromosome aberrations and micronuclei with lymphoid blood. 方法 对我科收治的放疗照射野包括食管,符合入组条件的病人,采用多种国际上常用的评价方式(RTOG临床评分、内镜评分、食管炎指数)评价急性放射性食管炎,并在不同的累积剂量点观察外周血淋巴细胞染色体畸变率、微核率,分析RTOG临床评分、累积剂量、内镜下发现、病理改变、外周血淋巴细胞染色体畸变率、微核率之间的关系,观察各项指标的诊断价值。
- Abstract Purpose and Methods : Single cell gel elect rophoresis ( SCGE) , sister chromatid exchanges ( SCE) ,chromosome aberrations are three methods to determine DNA damage and repair. 摘要 目的与方法:单细胞凝胶电泳技术(SCGE) 、姐妹染色单体交换法(SCE) 和染色体畸变分析法均能被用来检测DNA 的损伤或修复。
- Ionizing radiation is known to cause DNA damage, including single-strand and double-strand DNA breaks (DSBs), and the un-repair of DNA damage, particularly DSBs, may cause chromosome aberrations. 电离辐射极易造成DNA的损伤,包括单链和双链的断裂,而受损的DNA若不能及时、有效地修复,尤其是双链断裂的修复缺陷,便会引起染色体断裂和细胞死亡,甚至形成肿瘤。
- Scientists have yet to settle on a term for the suite of chromosomal aberrations seen in cancer. 对于出现在癌症的这套染色体变异,科学家还没确定要如何称呼。