Clinical Relevance: Although bupivacaine is the most commonly used local anesthetic for intra-articular analgesia, the demonstrated toxicity to human articular chondrocytes is cause for concern.

• 临床意义：虽然布比卡因是术后最常用的消除关节内疼痛的局麻药，但是己证实的对人体关节软骨细胞的毒性令人担忧。