Con clu sion Infection and replication of hepatitis B virus in patients with negative HBV DNA still coexist,and combined determination of the four parameters can reflect objectively the degree of replication and infection.

• 结论HBVDNA阴性患者HBV复制和感染仍有并存,四项指标联合检测更能客观反映HBV复制与感染程度。