Con clu sion There were significant differences of both sili-ca-induced cell proliferation inhibition and hprt gene mutation between rat lung fibroblasts and type II epithelial cells.

• 结论石英对大鼠肺成纤维细胞和肺泡II型上皮细胞的细胞毒性及对hprt基因致突变作用强度存在明显差异。