Conclusion BLU was found frequently hypermethylated and absent of mRNA expression in bladder carcinoma.Hypermethylation of BLU may contribute to its transcription inactivation.

• 本研究通过检测BLU基因在膀胱癌中的甲基化状态和转录水平，以期为膀胱癌甲基化谱增加一名新成员，并探讨该基因在膀胱癌发生中的作用。