Conclusion Experimental model of bile duct occlusive fibrosis in neonatal dog can be established by BDL or BDL/S, and the latter is more successful.

• 结论对幼犬进行单纯胆总管结扎或胆总管结扎后切断都可成功制作出胆管阻塞性肝纤维化模型，但后者成功率更高；幼犬胆管阻塞后形成肝纤维化比较快，自发逆转率低。