Conclusion GP could increased the cytotoxity and the intracellular accumulation of chemotherapeutic drugs in MDR-associated tumor cells.GP may be a promising MDR modulator.

• 结论GP能促进抗癌药物在MDR细胞内的累积，增强抗癌药物对MDR细胞的细胞毒作用，逆转肿瘤多药耐药。