Conclusion The changes in the intestinal mucosal TJ structure and function might contribute to altered bowel evacuation in patients with irritable bowel syndrome.

• 结论IBS患者的排便性状改变可能与紧密连接的结构和功能改变有关，紧密连接的开放性增强可能是导致腹泻性IBS腹泻的原因之一。