Conclusion:GM-CSF can activate the signal pathway and gene expression in the osteoclast, at the same time, express gene result to proliferation of osteoblast.

• 结论GM-CSF和其诱导的破骨细胞促进成骨细胞增殖、分化,可能是通过破骨细胞内GM-CSF介导的信号通路而发挥作用。