Conclusion:Processed Products of Semen Strychni is lower toxicity than its crude drug,the study is useful to build up the standardization of Chinese herb slices.

• 结论：炮制可降低马钱子的毒性，不同炮制方法的减毒作用有差异，通过比较研究有利于实现饮片规范化、标准化。