Conclusions In patients with euolemic or hyperolemic hyponatremia, tolaptan, an oral asopressin 2-receptor antagonist, was effectie in increasing serum sodium concentrations at day 4 and day 30.

• 结论：对于等容量性和高容量性低钠血症的患者，用口服选择性血管加压素2受体拮抗药托伐普坦治疗4天和30天后均能有效提高血钠浓度。