Conclusions:The prescription of gu yan has good effect on anti-inflammation, detumescence and alleviating pain.The prescription of gu yan is effective on treating KOA, and is worth of further study.

• 结论：“骨炎方”具有较好的抗炎、消肿、镇痛的作用，在临床“骨炎方”治疗膝OA是有效的，值得深入研究。