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- DNA methylation patterns in the CpG island of RASGRF2, RASGRF2 and FBN2 were determined by the method of MSP. 采用 MSP分析 RASSF1A、 RASGRF2 和 FBN2 是否存在启动子异常甲基化。
- Hypermethylation of CpG island in the promoter region of FHIT gene is a early and common alterration. 子宫内膜癌组织中存在FHIT基因启动子区域CpG岛的甲基化 ,CpG岛的甲基化与临床病理特征之间无相关性。
- Methylation Specific Polymerase Chain Reaction (MSP) was used to test the CpG island methylation status of cancer related genes P16, MGMT and hMLH1. 应用甲基化特异性PCR法检测癌组织、边缘组织和正常食管粘膜组织中肿瘤相关基因P16、MGMT和hMLH1启动子区甲基化状态，分析DNA异常甲基化是否与食管癌临床特征和环境因素间存在联系，并探讨食管癌相关基因异常甲基化与叶酸代谢酶基因MTHFR C677T多态间的关系。
- Results Different degree of CpG island hypermethylation of MT3 gene existed in all the four cell lines of esophageal squamous cell carcinoma. 结果四种食管鳞状细胞癌细胞株的MT3基因均存在不同程度的CpG岛超甲基化。
- Conclusions CpG island hypermethylation of MT3 gene in cell lines of esophageal squamous cell carcinoma can inhibit their mRNA expressions. 结论食管鳞状细胞癌细胞株中MT3基因CpG岛超甲基化可抑制其mR-NA表达;
- CpG island demethylation facilitates gene transcription, resulting in oncogene activation, chromosome instability, mutation hotspot, and retrotransposon replacement. CpG岛高甲基化抑制基因转录表达，导致众多抑癌基因转录沉默(transcription silencing)，蛋白表达缺郑州大学2 003年硕士研究生毕业论文胃疮中环氧合酶一2基因5’端cpG岛去甲基化与蛋白表达的关系及临床意义(中文摘要)失。
- Methods The methylation status of CpG island of AR gene promoter in 3 leukemic cell lines and 15 leukemic bone marrow cells was detected by methylation specific PCR(MSP). 方法应用甲基化特异性PCR技术(methylation specific PCR,MSP)检测3种白血病细胞株及15例患者骨髓标本雄激素受体基因甲基化状态。
- Using methylation specific PCR (MSP) to detect the CpG island methylation changes of PRA & PRB promoters in the leukemia cell lines before and after 5-Aza CdR treatments and the MG88 transfection. 利用MSP检测白血病细胞株在5-Aza CdR处理前后、MG88的转染前后PRA、PRB启动子CpG岛甲基化状态。
- In order to explore the role of p15 INK4B gene with highly methylated CpG island in the pathogenesis of leukemia, the expression levels of p15 INK4B gene was detected in patients with AML and CML. 为探索 p15 INK4B基因在CpG岛高甲基化对白血病发病机制的重要作用 ,应用敏感的甲基化特异的MSP PCR的测定方法 ,测定了 p15 INK4B基因在急性粒细胞白血病 (AML)和慢性粒细胞白血病 (CML)中甲基化的表达变化。
- CpG island methylation of FHIT was detected in 31.13% of the plasma samples, and in 53.33% of the tissue samples. The total concordant rate of methylation status between plasma and tissue samples in FHIT gene was 80.00%. 结果在宫颈癌患者血浆和组织中;FHIT基因5′端CpG岛甲基化率为30.;46%25和53
- Entropy-based divergence measures have provided an impelling tool in evaluating sequence complexity, predicting CpG island, and detecting borders between coding and non-coding DNA regions etc. 摘要 在分析DNA序列复杂度、预测基因编码区和非编码的DNA边界识别等问题中，以熵为基础构造的离散量度量提供了一种强有力的工具。
- Methylation of hMLH1 and COX-2 gene promoter CpG islands may both occur in the development of MSI gastric carcinoma. 在MSI胃癌(尤其是MSI-H型胃癌)的发生、发展过程中可能同时出现了hMLH1和COX-2基因启动子CpG岛的甲基化(即表型遗传修饰)。
- Methylation of hMSH2 gene promoter CpG islands was not detected in gastric carcinoma or normal tissues. hMSH2基因启动子CpG岛在胃癌及正常组织中均未检测到甲基化。
- The methylation rate of hMLH1 gene promoter CpG islands in MSI-H was higher than that in MSS (P<0.01). 在MSI-H组hMLH1基因启动子CpG岛甲基化率显著高于MSS组(P<0.;01);
- Cases with methylation of COX-2 and hMLH1 gene promoter CpG islands in gastric carcinoma were 8 and 13, and they were not detected in normal tissues. COX-2和hMLH1基因启动子CpG岛甲基化在43例胃癌中分别有8例和13例,正常组织中未检测到。
- CpG islands of PRA and PRB promoters were demethylated and PRAB and PRBmRNA were re-expressed after 5-Aza CdR treatment. 5-Aza CdR处理L-60、K562、Jurkat后，PRA、PRB启动子CpG岛发生去甲基化，PRAB、PRB mRNA恢复表达。
- Conclusion Our findings showed that there was hypermethylation of CPG islands in the promoter area of RASSF1A in breast cancer . 乳腺癌的发生机制尚不清楚，尚没有良好的治疗方法，有关人体乳腺癌组织中的甲基化状态与临床病理的关系较少见报道。
- I'd buy an island if I had lots and lots of money. 果真我有许多许多钱，我就买一个小岛。
- Nobody has ever set foot on that island. 没有人曾经登上过那个岛屿。
- This island is no longer a dependency of the USA. 这个小岛不再是美国的属地。
