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Cyelin dependent kinases 细胞周期蛋白质依赖激酶类
Methods Expressions of cyclin E and cyclin dependent kinases 2(cdk2)in 38 cases of lung cancer and 6 cases of normal lung tissues were examined by immunohistochemistry. 方法 :应用免疫组化方法检测细胞周期蛋白E(cyclinE)和细胞周期蛋白依赖性激酶 2 (cdk2 )在 38例肺癌和 6例正常肺组织中的表达状况。
Using labe1led streptavidin - biotin (LSAB) methed, we exandned the expression of cyclin- dependent kinases 4 inhibitor P 16 (CDK4I ) in 83 cases of human non-sman cull lung cancer,the average rate of P16 protein positive expression was 65. 93%. 为研究CDK4I/P16与非小细胞肺癌的发生及发展的关系，应用免疫组化LSAB法研究了83例肺癌手术标本中CDK4I蛋白的表达。结果显示，CDK4I蛋白表达平均阳性率为65.;93%25。
Methods: The expression of cyclins dependent kinases (CDK4) in epithelial cells in the samples in 40 cases of OLP and in 10 cases of healthy controls was observed by immunohistochemical method. 方法：通过免疫组织化学方法，观察了 40例OLP上皮细胞中 CDK4（细胞周期蛋白依赖性激酶，cyclins dependent kinases）的表达状况。
To study the effect of the specific cyclin dependent kinases (CDKs) inhibitor Olomoucine on apoptosis induced by low potassium and its mechanisms by using agarose gel eletrophoresis and SAPK/JNK assay kit rto measure SAPK/JNK activity. 目的 :研究化学合成的蛋白激酶抑制剂Olomoucine对低钾诱导的小脑颗粒神经元凋亡的作用及机制。方法 :体外神经元培养、凝胶电泳和SAPK/JNK分析盒测定JNK(c -Jun氨基末端激酶 )活性。
Cell cycle is mainly regulated by cyclin, cyclin dependent kinase(CDK) and cyclin dependentkinase inhibitor (CDKI). 细胞周期主要是由细胞周期蛋白(cyclin)，细胞周期蛋白依赖性激酶(CDKs)和CDK抑制蛋白(CDKI)来调控的。
Protein serine theronine phosphatase inhibitor or cyclin dependent kinase( CDK) inhibitors could abolish the enhancement. 而蛋白丝氨酸苏氨酸磷酸酯酶抑制剂以及细胞周期蛋白依赖性激酶(DK)制剂可阻断该凋亡敏感性增强效应。
Formation, activition and degradation of cyclin - dependent kinase(CDK) and cyclin complex are the main molecular foundation. 其中细胞周期素依赖性激酶(cyclin-dependent kinase，CDK)与细胞周期素(cyclin)复合体的形成、激活与失活是细胞周期调控的主要分子基础。
In the recent years, cyclin, cyc-lin dependent kinase and cyclin dependent kinase inhibitor have important effect in cell cycle modulation. 近年来发现细胞周期素(Cyclin)、细胞周期蛋白依赖激酶(Cyclin dependent kinase，CDK)和细胞周期蛋白依赖性激酶抑制因子(Cyclin dependent kinase inhibitor，CKI)在真核生物细胞周期调控有重要作用。
P21WAF1 is a kind of cyclin dependent kinase inhibitor, it can be bind to several kinds of cyclin/CDK compounds and arrest the cell cycle. P21~(WAF1)是一种CKI，它可与多种cyclin/CDK复合物结合，引起细胞周期阻滞。
It is well known that cell cycle in eukaryotic cells is controlled by various complexes composed of cyclin and cyclin dependent kinase (CDK). 真核细胞周期是受细胞周期蛋白(cyclin)和细胞周期蛋白依赖激酶(cyclin dependent kinase,CDK)组成的蛋白复合体调控。
Objective To investigate roles of cyclin dependent kinase 4 (CDK4) in nordihydroguaiaretic acid (NDGA) induced inhibitory effect on proliferation of human malignant glioma cells. 目的探讨细胞周期蛋白依赖性蛋白激酶 4(CDK4)在去甲二氢愈创木酸 (NDGA)抑制人恶性胶质瘤细胞系SHG 44细胞增殖中的作用。
Objective To study the role of cycline dependent kinase 4(CDK4) in the malignant transformation of human fetal lung diploid fibroblast cell(2BS) induced by silica. 目的探讨细胞周期蛋白依赖激酶K4(CDK4)在石英致人胚肺成纤维细胞(2BS)恶性转化过程中所起的作用,为石英致癌机制提供理论依据。
Yeast regulatory factor PHO85, which is a cyclin?dependent kinase (CDK), participates in the regulation of the cell cycle control and the expression of the acid phosphatase gene. 酵母调控因子PHO85是一个依赖于细胞周期蛋白（cyclin）的蛋白激酶（CDK），参与对细胞周期和酸性磷酸酯酶基因表达的调控。
Objective: To study the relationship between cyclin dependent kinase 4 (CDK4),PTEN protein expression and carcinogensis、progression and recurrence of endometrial carcinoma . 目的：探讨PTEN、CDK4蛋白表达与子宫内膜癌的发生、发展及复发的关系。
All effects are dependent on their causes. 一切的结果都基于它们的原因。
They are dependent on public charity. 他们依赖公众的赈济。
You can't depend on the train arriving on time. 千万不要认为这列火车能正点到达。
The child is dependent on his parents for support. 这个小孩靠他的父母养活。
The activity of cyclin - Cdk complexes is affected by cyclin - dependent kinase inhibitors including P27kip1. P27kIp1 protein binds to cyclin D - Cdk4, cyclin E - Cdk2 and cyclinA - Cdk2 complex inhibiting their activities during the cell cycle. 目前发现的CDKI按结构和功能的不同可分成两大类：一类为Cip/Kip(CDK-interacting protein/kinase inhibition protein)，包括p21~(Cip1)、p27~(kip1)、p57~(kip2)等。