DNA methylation catalyzed by DNA methyltransferases interacts with histone modification to inhibit gene transcription,induce gene silencing at the participation of many regulators.

• DNA甲基化由DNA甲基转移酶催化,在多种调节因子的参与下,与组蛋白修饰相互作用,抑制基因转录,导致基因沉默。