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- The trace residues were mapped onto the active site of CaNMT. Trp126,Asn175 and Thr211 are highly conserved trace residues and do not interact with current NMT inhibitors,which are potential novel drug binding sites for the novel inhibitor design. 通过对白色念珠菌NMT活性位点中药物结合位点的研究发现,Trp126,Asn175和Thr211是NMT家族的高度保守残基,而且不与已有的抑制剂发生直接的相互作用,因此将是发现新型NMT抑制剂的重要药物结合位点。
- Drug binding site 药物结合位点
- This paper discusses the effects of drug binding and extractable impurities from syringe filters on dissolution data. 本文讨论了药物结合以及可从针头式过滤器中提取的杂质对溶出度数据的影响。
- The binding site of Bt-R3 with CrylAb was located in extracellular domains of Bt-R3 protein. Because the E. 且该受体蛋白与Cry1Ab的结合部位位于Bt-R3受体蛋白的胞外结构域。
- Also the modeling presents the ligand binding site, active site and the putative binding of tRNA Trp . 模建结果对配基结合位点和活性位点以及可能与tRNATrp结合的方式也给出了预测。
- Ti ue binding: Drugs bind to many su tances other than protei . 组织结合 除蛋白质外,药物还可以和其他许多物质结合。
- Proteins encoded by resistance genes usually contain leucine-rich repeats (LRR)and nucleotide binding site NBS). 植物抗病基因编码的蛋白,大多含有富氨酸重复单位(LRR)和核苷酸结合位点(NBS)等结构。
- However, MSP cytoskeleton has no polarity, ATP binding site and motor protein, which are different from actin. 与肌动蛋白不同,精子主要蛋白没有分子极性、ATP结合位点和马达蛋白。
- The binding site was in the peripheral rail fence of polyethylene glycol chain for CAS and in alkyl inner nuclear of miclle for TB. 并通过比较染料在不同溶剂的吸收光谱 ,推断了表面活性剂与染料相互作用点的位置 ,证明了极性较大的 CAS位于聚氧乙烯链的外围“栅栏”中 ,而极性较小的 TB则位于胶束的烷基“内核”
- Binding a transcription factor to its binding site may cause many physiological functions;defects in the binding may cause diseases. 转录因子与启动子的相互作用可以影响很多重要的生理功能,而其缺陷可以引起各种疾病。
- Morphological studies revealed the existence of GABAA receptor, including its benzodiazepine binding site, and GABAB receptor in globus pallidus. 形态学研究揭示苍白球存在GABAA受体及其苯二氮卓结合位点和GABAB受体。
- The binding isotherms of CDH adsorbed on the above substrates were a straight line in Scatchard plot analysis, indicating that the binding fitted to the one binding site model. 与纤维素酶明显不同, 该酶的Scatchard 吸附曲线都是一条直线, 为典型的单结合位点模型(one?binding?site model) 。
- ER binding sites in tumor were determinedby tritiated estradiol binding method. 用氚标记雌二醇结合法测定瘤内的er结合位点数。
- The human vaccinia virus B1R kinase related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein. 人类牛痘病毒B1R激酶相关激酶VRK1可使肿瘤抑制蛋白p53的Ser18磷酸化,该位点正是mdm-2的结合位点。
- Morphological studies revealed the existence of GABA(subscript A) receptor, including its benzodiazepine binding site, and GABAB receptor in globus pallidus. 形态学研究揭示,苍白球存在GABA(下标 A)、受体及其苯二氮卓结合位点和GABA(下标 B)受体。
- In the study of the electrochemical properties, various of triphenylamine derivaties have different oxygen binding site and they make elecropolymerization happen or not. 在电化学研究方面,不同的三苯胺衍生物由于氧基的位置不同,使得取代基在间位的化合物有不错的电聚合效果;
- In agreement with the in vitro effect, activation of GABAB receptor, GABAA receptor benzodiazepine binding site and blockade of GABA uptake cause rotation in behaving animal. 与离体实验结果相一致,激活苍白球GABAB受体和苯二氮卓结合位点及阻断GABA重摄取可引起整体动物旋转行为。
- The nurse diluted the drug with saline water. 护士用生理盐水把药加以稀释。
- It is suggested that there are ABA binding sites on mitochondria which may act as receptors. 暗示 ,线粒体上可能存在具有受体功能的aba结合位点
- It reversed the inhibition on DAT by cocaine, but did not compete for the same binding sites on DAT with cocaine. 它能够翻转可卡因对DAT的抑制,但不竞争可卡因和DAT的结合位点。