During early embryo development, Foxd3 mRNA has been detected in blastocyst-stage embryos and throughout the epiblast of the 6.5 days postcoitum (dpc) embryo.
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- 实验发现Foxd3基因敲除的胚胎在E6.;5天死亡;并且表现为epiblast的减少;取而代之的是近端胚外组织(proximal extraembryonic tissue)。