EBB has a strong reversal effect on MDR in MCF-7/ADR cell,which may be achieved by enhancing the arrestment of MCF-7/ADR cells at G_2/M phase and increasing intracellular drug concentration.

• EBB对MCF-7/ADR细胞具有较强的逆转多药耐药作用,其可能的逆转机制在于增强ADR对耐药细胞在G2/M期的阻滞以及抑制P糖蛋白外排泵作用。