FK228 with a special depsipeptide may efficiently pass through the cellular membrane and exert a prominent anti-tumor activity by inhibiting histone deacetylase.

• FK228具有特殊的缩酯环肽结构,可有效透过细胞膜,通过抑制组蛋白去乙酰酶而显示良好的抗肿瘤活性。