From highly Pare m-trifluoromethyl aniline, the Flutamide is prepared by acylation with isobutyl chloride and nitration with assistant S.

• 以高纯度间三氟甲基苯胺为原料，经异丁酰氯酰化，再在助剂S存在下进行硝化制得氟他胺。