Furthermore, the effect of OFQ on pituitary LH release of ovariectomized rats and the expression of OFQ and ORLl receptor of MBH in estrous cycle was also studied for probing its pharmacological and physiological effects on the release of pituitary LH.

• 同时为了研究下丘脑孤啡肽对垂体LH分泌的药理作用以及它参与性周期调节的可能的生理作用,拓展对下丘脑孤啡肽及其受体生物学功能的认识,本文还观察了侧脑室给予孤啡肽对去卵巢大鼠垂体分泌LH的影响以及下丘脑孤啡肽及其受体表达在大鼠性周期中的变化。