GRP94 is a stress protein whose transcriptional level increases under several physiologial and pathological conditions. This is the unfolded protein response ( UPR) pathway which associates with the signal transferring from ERs to nucle-us.

• GRP94作为应激蛋白，其转录水平在许多生理和病理条件下都可明显升高，与此相关的从内质网到细胞核的信号传导通路就是未折叠蛋白反应（the unfolded protein response,UPR）通路。