HCV-NS3-T_H1 plasmid vaccine based on CLIP substitution could been expressed efficiently in Mammalia cell line and stimulate CD4~+ T_H1 mediated cellular immune response. It might be a potential candi- date for HCV therapeutic vaccine development.

• 基于Ii分子的HCV内源性靶向基因疫苗能够在真核细胞中表达并刺激小鼠产生CD4~+ T_H1类型的细胞免疫,为HCV的疫苗开发提供了一个新思路。