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- Keywords Zanthoxylum dissitum Hemsley;aurantiamide acetate;chemotaxonomy;HIV 1 integrase; 蚬壳花椒;橙黄胡椒酰胺;化学分类学;HIV-1整合酶;
- Raltegravir, sold under the trade name Isentress, is a 'first-in-class' HIV integrase inhibitor. Raltegravir;在美国以商标名称Isentress出售的新药;是最新HIV病毒抑制剂.
- Two are "integrase inhibitors" that block the HIV genetic material from attaching to the host cell's DNA. 其中两种药物是“整合?抑制剂”，它可以阻止艾滋病病毒的遗传物质附加到宿主细胞的DNA中。
- Human immunodeficiency virus type 1 integrase is an essential enzyme for retroviral replication and the rational target of anti AIDS drugs. 1整合酶是逆转录病毒复制所必要的酶,因此也是抗艾滋病药物作用的一个合理靶点。
- Objective Plasmid of AAV vector with HIV 1 gag and gp 120 were constructed respectively. 目的 构建带有HIV 1gag或 gp12 0基因的重组腺病毒伴随病毒AAV HIV gag或AAV HIVgp12 0。
- The HIV 1 capsid protein(CA) plays an essential role in viral core assembly and maturation. 人类免疫缺陷病毒(HIV)的壳体蛋白(CA)在HIV病毒的组装和成熟过程中起着至关重要的作用。
- The discovery of HIV 1 corecptor and the role of the coreceptor CCR 5 in HIV 1 infection and disease progression are reviewed. 简述了HIV－1辅助受体的发现过程及辅助受体CCR－5在HIV－1感染及发病过程中的作用。
- The domain epidemic strains in the area were mainly from HIV 1 American European strain, B subtype of Thailand strain and their derivative strains. 这一结果提示，在进化上云南瑞丽HIV?1流行毒株间有非常密切的关系，在这一时期该地区的流行毒株以HIV?1美欧株、泰国株B亚群及其衍生株为主。
- The amino acid sequence in all of these 6 clones is the same,HYEFWAWNWEAN, which is hydrophobic as N terminal of C34.Conclusion This phage display peptide can mimic the epitope of HIV 1 gp41 CHR ,and bind with HIV 1 gp41 NHR. 上述 6个阳性克隆经DNA测序 ,氨基酸序列相同 :HYEFWAWNWEAN ,其明显的疏水性质类似于C34N末端 ,特异性鉴定显示这些克隆均能够与HIV 1gp4 1N多肽结合。 结论 该噬菌体克隆展示肽可模拟HIV 1gp4 1CHR多肽表位 ,并可与N多肽结合
- Thus, emphasis should be laid to search for new integrase inhibitors with high activities to provide a new way of treating AIDS. 应着眼于寻找高活性的整合酶抑制剂，为治疗艾滋病提供新的途径。
- AIM: To construct the recombinant adenoviral vector carrying antisense RNA to chemokine receptors CCR5 and CXCR4 and to obtain recombinant adenovirus, which will be used to resist HIV 1 infection. 目的 :构建趋化因子受体CCR5 ;CXCR4双靶区反义RNA重组载体并获取重组腺病毒以用于抗HIV 1基因治疗的研究 .
- Methods 24 HIV 1 infected patients and 13 normal controls were tested and a three color flow cytometry was used to detect the activation marker HLA DR and the coreceptor CCR5, CXCR4 expressions in blood samples taken from the patients and the controls. 方法 用三色标记法流式细胞术检测 2 4例HIV 1感染者及 13例健康对照的抗凝血标本 ,分析活化标志物HLA DR及第二受体CCR5、CXCR4的表达等指标。
- This review focuses on the recent developments of integrase inhibitor.And the sites of action of integrase inhibitors are discussed so as to design the new anti AIDS drugs. 本文综述了近3年来整合酶抑制剂的发展现状并对药物设计时可以考虑的几个作用位点进行了讨论。
- The Methods for Screening HIV Integrase Inhibitors in vitro HIV整合酶抑制剂体外筛选方法研究进展
- The Research Progress of Diketo Acid HIV Integrase Inhibitors 二酮酸类HIV整合酶抑制剂研究进展
- Keywords HIV;integrase inhibitors;diketo acid derivatives; 艾滋病毒;整合酶抑制剂;二酮酸衍生物;
- Keywords HIV 1 infection;Viral load;NASBA; 关键词HIV-1感染;病毒载量;等温核酸序列扩增技术（NASBA）;
- Keywords HIV 1;capsid;virus like particle;vaccine; 壳体蛋白;病毒样颗粒;疫苗;
- This city has a population of more than 1,000,000. 这个城市人口超过一百万。
- integrase inhibitor 整合酶抑制剂
