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- Antiproliferation and apoptosis induction effects of HMG CoA reductase inhibitor on ADPKD cyst-lining epithelial cell line HMG GoA还原酶抑制剂对ADPKD囊肿衬里上皮细胞增殖抑制和凋亡诱导的研究
- The Key Enzyme of Cholesterol Synthesis Pathway:HMG CoA Reductase and Disease 胆固醇合成途径的关键酶:HMG辅酶A还原酶和疾病
- HMG CoA reductase β-羟-β-甲基戊二酸单酰辅酶A还原酶
- Objective:To synthesize the aldose reductase inhibitor fidarestat. 目的:合成醛糖还原酶抑制剂非达司他。
- AIM: To investigate the effect of hydroxy-methylglutaryl-CoA (HMG-CoA) reductase inhibitor, fluvastatin, on airway remodeling in asthmatic rats. 目的:观察羟甲基戊二酰辅酶A(HMG-CoA)还原酶抑制剂氟伐他汀对大鼠哮喘模型气道重建的影响.
- SNK-860 is a potent aldose reductase inhibitor with high ARJ activity and low side effects, which makes it a promising drug for diabetic neuropathy. SNK-860是一种新型的海因类醛糖还原酶抑制剂,对醛糖还原酶的抑制作用强而专一,而且不良反应小,是治疗糖尿病性神经病变的安全有效的药物。
- The synthesis of epalrestat,an aldose reductase inhibitor, was improved. The yield of its intermediate 3-carboxymethyl rhodanine was raised to 76.4%. 对醛搪还原酶抑制剂依帕司他的合成工艺作了改进,使中间体绕丹宁乙酸的收率提高到76.4%25。
- Conclusion The structure-activity relationships of methylquinolinoneacetic acids, as a novel type of aldose reductase inhibitor, should be investigated further. 结论 甲基喹啉酮乙酸类化合物作为新型醛糖还原酶抑制剂,其构效关系值得进一步研究。
- methylhydroxyglutaryl CoA reductase 甲基羟戊二酰辅酶A还原酶
- hydroxymethylglutaryl CoA reductase 羟甲基戊二酸单酰辅酶A还原酶
- OBJECTIVE: To observe the effect of aldose reductase inhibitor(ARI) on the activity of corneal aldose reductase (AR) and Na+-K+ATPase , and on corneal lesions in early diabetic rats and to investigate the protective mechanism. 目的:观察醛糖还原酶抑制剂(ARI)对糖尿病早期大鼠角膜组织中醛糖还原酶活性(AR)、钠-钾-ATP酶活性(Na+-K+ATPase)和角膜病变的影响,并探讨其防治效应及其机制。
- Objective To observe the effects of HMG-CoA reductase inhibitor on the expression of LDL receptor in liver of nephrotic rats and the mechanism of Lovastatin treating hyperlipidemia in nephrotic syndrome. 目的观察在大鼠肾病综合征模型中使用3-羟基-3-甲基戊二酰辅酶A(HMG-CoA)还原酶抑制剂洛伐他汀(Lovastatin)治疗对肝脏低密度脂蛋白(LDL)受体表达的影响,探讨他汀类药治疗肾病综合征高脂血症的机制。
- Part IIThe second part of this thesis is the synthesis of the aldose reductase inhibitor SNK-860. SNK-860 is a potent aldose reductase inhibitor with high ARJ activity and low side effects, which makes it a promising drug for diabetic neuropathy. 本论文的第二部分是醛糖还原酶抑制剂SNK-860的合成研究。 SNK-860是一种新型的海因类醛糖还原酶抑制剂,对醛糖还原酶的抑制作用强而专一,而且不良反应小,是治疗糖尿病性神经病变的安全有效的药物。
- Enoyl-acyl carrier protein reductase inhibitor 脂烯酰基酰基载体蛋白还原酶抑制剂
- HMG-CoA Reductase Inhibitor HMG-CoA 还原酶抑制药
- The considerable interest has been evoked in using of aldose reductase inhibitors as potential therapeutic ad... 醛糖还原酶抑制剂作为潜在的治疗心肌梗死的有效措施引起了研究者的关注。
- hydroxymethylglutaryl-CoA reductase inhibitor 羟甲基戊二酰基CoA还原酶抑制剂
- hydroxymethlglutary CoA reductases 3-羟基-3.;甲基戊二酸单酰辅酶A还原酶
- dihydrofolate reductase inhibitor 二氢叶酸还原酶抑制剂
- For screening aldose reductase inhibitors(ARI) from traditional medicinal herbs,the assay method of pig lens AR was established and 40 traditional medicinal herbs were screened. 为从大量中草药及其化学成份中筛选有效低毒的醛糖还原酶抑制剂(ARI),建立了猪晶状体AR的测定方法,其研究了知母等40种中药水提取液对AR的抑制作用。