HPLC analysis of the TW10 fermentation culture showed that TW10 did not synthesize avermectins anymore, suggesting that the synthesis of avermectins were dominated by bldA_a.

• 摇瓶发酵TW10菌株并对发酵产物进行HPLC分析,发现TW10菌株均不合成阿维菌素组分,提示阿维菌素的合成受bldAa调控;