HPV16 E7 specific siRNA expression vector can effectively inhibit the expression of E7 gene and partly reverse the malignant phenotype of CaSki cells,it may be one of the ideal strategies for gene therapy of cervical cancer.

• HPV16E7siRNA表达载体能有效地抑制宫颈癌CaSki细胞E7基因的表达,部分逆转其恶性表型。 因此它有望成为宫颈癌基因治疗的新策略之一。