Hence, we investigated whether RNA-dependent DNA methylation might operate in human cancers to mediate epigenetic silencing using the endogenous gene CDH1 as a potential target.

• 因此，我们用内源的CDH1基因作为可能的靶基因研究RNA依赖的DNA甲基化是否也在人类的癌症中参与了对基因的转录沉默。